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What is the difference between omeprazole and famotidine?

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Are Pepcid and Prilosec the Same Thing? Pepcid (famotidine) and Prilosec (omeprazole) are used to treat and prevent recurrence of stomach and duodenal ulcers. Pepcid (famotidine) is an H2-blocker and Prilosec is a proton pump inhibitor (PPI). Pepcid and Prilosec are available over-the-counter (OTC) and in generic form.
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